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Title

Parkinson Disease and Smoking Revisited: Ease of Quitting Is an Early Sign of the Disease (Neurology)

Publication Topics

Tobacco/Smoking; Chronic Condition Prevalence; Functional Impairment

Publication Type

Journal Article

Publication Date

2014-10-12T07:00:00Z

Author 1

<a onclick="OpenPopUpPage('http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=255&RootFolder=*', RefreshPage); return false;" href="http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=255&RootFolder=*">Beate Ritz, MD, PhD</a>

Author 2

<a onclick="OpenPopUpPage('http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1338&RootFolder=*', RefreshPage); return false;" href="http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=1338&RootFolder=*">Pei-Chen Lee</a>

Author 3

<a onclick="OpenPopUpPage('http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=79&RootFolder=*', RefreshPage); return false;" href="http://healthpolicy.ucla.edu/_layouts/listform.aspx?PageType=4&ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&ID=79&RootFolder=*">Onyebuchi A. Arah, MD, PhD, MPH</a>

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Abstract

​Authors assess whether the ability to quit smoking is an early marker of Parkinson disease (PD) onset rather than tobacco being "neuroprotective" by analyzing information about ease of quitting and nicotine substitute use.

For the case-control study, the authors identified 1,808 patients with PD diagnosed between 1996 and 2009 from Danish registries, matched 1,876 population controls on sex and year of birth, and collected lifestyle information.

Fewer patients with PD than controls ever established a smoking habit. Among former smokers, those with greater difficulty quitting or using nicotine substitutes were less likely to develop PD, with the risk being lowest among those reporting "extremely difficult to quit" compared with "easy to quit." Nicotine substitute usage was strongly associated with quitting difficulty and duration of smoking, i.e., most strongly among current smokers, followed by former smokers who had used nicotine substitutes, and less strongly among former smokers who never used substitutes.

Data from the study supports the notion that patients with PD are able to quit smoking more easily than controls. These findings are compatible with a decreased responsiveness to nicotine during the prodromal phase of PD. We propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent "neuroprotective" effect of smoking observed in epidemiologic studies is due to reverse causation.

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Article 1

Journal Article: Parkinson Disease and Smoking Revisited: Ease of Quitting Is an Early Sign of the Disease

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Created at 6/16/2016 1:48 PM by i:0#.f|uclachissqlmembershipprovider|celeste
Last modified at 6/16/2016 1:50 PM by i:0#.f|uclachissqlmembershipprovider|celeste