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Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (Journal of Community Genetics)

Publication Topics

Cancer; 2005 California Health Interview Survey (CHIS 2005)

Publication Type

CHIS Journal Article

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Author 2

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Author 4

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Author 5

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Author 6

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Summary: This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary care to improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane library were searched from January 1980 to October 2017. The authors included randomised controlled trials (RCT) and non-randomised studies of interventions (NRSI). Primary outcomes were cancer incidence, cancer-related clinical outcomes or the identification of cancer predisposition; secondary outcomes were the appropriateness of referral, uptake of preventive strategies and cognitive and psychological effect. 

Findings: From 11,842 abstracts, 111 full texts were reviewed and three eligible studies (nine articles) identified. Two were cluster RCTs and one NRSI; all used risk assessment software. No studies identified our primary outcomes, with no consistent outcome across the three studies. In one RCT, intervention improved the proportion of genetic referrals meeting referral guidelines for breast cancer. In the other RCT, there was no difference in screening adherence between the intervention and control group. However, there was borderline increased risk perception in the subgroup that under-estimated their colon cancer risk. In the NRSI, there was no change in psychological distress in patients at increased familial breast cancer risk, but population risk patients had reduced anxiety after intervention. Future studies should have better-defined comparator groups and longer follow-up and assess outcomes using validated tools.


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CHIS Journal Article : Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review

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Version: 3.0
Created at 7/10/2020 5:00 PM by i:0#.f|uclachissqlmembershipprovider|bijalluhar
Last modified at 7/13/2020 2:11 PM by i:0#.f|uclachissqlmembershipprovider|venetia