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Association of HIV Status and Treatment Characteristics with VIA Screening Outcomes in Malawi: A Retrospective Analysis (PLos One)

Publication Topics

Access to Health Care; Barriers to/Disparities in Health Care; Screening for Early Disease Detection; Use of Health Services; Cancer; Women; Urban/Rural Populations

Publication Type

Journal Article

Publication Date


Author 1

<a onclick="OpenPopUpPage('http:\u002f\\u002f_layouts\u002flistform.aspx?PageType=4\u0026ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}\u0026ID=1997\u0026RootFolder=*', RefreshPage); return false;" href=";ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&amp;ID=1997&amp;RootFolder=*">Samuel Lewis</a>

Author 2

<a onclick="OpenPopUpPage('http:\u002f\\u002f_layouts\u002flistform.aspx?PageType=4\u0026ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}\u0026ID=1998\u0026RootFolder=*', RefreshPage); return false;" href=";ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&amp;ID=1998&amp;RootFolder=*">Misheck Mphande</a>

Author 3

<a onclick="OpenPopUpPage('http:\u002f\\u002f_layouts\u002flistform.aspx?PageType=4\u0026ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}\u0026ID=1305\u0026RootFolder=*', RefreshPage); return false;" href=";ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&amp;ID=1305&amp;RootFolder=*">Corrina Moucheraud, ScD, MPH</a>

Author 4

<a onclick="OpenPopUpPage('http:\u002f\\u002f_layouts\u002flistform.aspx?PageType=4\u0026ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}\u0026ID=151\u0026RootFolder=*', RefreshPage); return false;" href=";ListId={7AAD61FA-4BCB-48C0-B0B7-87AFDC3673EF}&amp;ID=151&amp;RootFolder=*">et al</a>

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Summary: Although evidence from high-resource settings indicates that women with HIV are at higher risk of acquiring high-risk HPV and developing cervical cancer, data from cervical cancer "screen and treat" programs using visual inspection with acetic acid (VIA) in lower-income countries have found mixed evidence about the association between HIV status and screening outcomes. Moreover, there is limited evidence regarding the effect of HIV-related characteristics (e.g., viral suppression, treatment factors) on screening outcomes in these high HIV burden settings.

This study aimed to evaluate the relationship between HIV status, HIV treatment, and viral suppression with cervical cancer screening outcomes. Data from a "screen and treat" program based at a large, free antiretroviral therapy (ART) clinic in Lilongwe, Malawi was retrospectively analyzed to determine rates of abnormal VIA results and suspected cancer, and coverage of same-day treatment.

Findings: Of 1,405 women receiving first-time VIA screening between 2017–2019, 13 (0.9%) had suspected cancer and 68 (4.8%) had pre-cancerous lesions, of whom 50 (73.5%) received same-day lesion treatment. There was no significant association found between HIV status and screening outcomes.

In this population of women living with HIV with high rates of ART coverage and viral suppression, HIV status was not significantly associated with abnormal cervical cancer screening results. Authors hypothesize that ART treatment and viral suppression may mitigate the elevated risk of cervical cancer for women living with HIV, and they encourage further study on this relationship in high HIV burden settings.


Article 1

Journal Article: Association of HIV Status and Treatment Characteristics with VIA Screening Outcomes in Malawi: A Retrospective Analysis

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Press Release

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Version: 2.0
Created at 2/1/2022 4:46 AM by i:0#.f|uclachissqlmembershipprovider|celeste
Last modified at 2/1/2022 4:57 AM by i:0#.f|uclachissqlmembershipprovider|celeste