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Differences in Chronic Conditions and Substance Use Among American Indian and Alaska Native Adults in California

Highlights

LGBP+ AIAN adults in California with hypertension are twice as likely to have uncontrolled high blood pressure (37%), compared with heterosexual AIAN adults (16%).

One-fourth of AIAN adults in California with higher incomes reported binge drinking, compared with 15% of AIAN with lower incomes.

Nearly one-third of LGBP+ AIAN adults in California used marijuana in the past month (32%), and nearly half of transgender and gender-expansive adults used marijuana in the past month (45%), compared with 19% of AIAN adults overall.

Summary

Published Date: July 23, 2026

American Indian and Alaska Native (AIAN) populations face significant chronic disease and substance use burdens compared to other populations. However, the differences that exist within this broader population remain understudied in California. Using combined 2020–2024 California Health Interview Survey (CHIS) data for AIAN adults, this policy brief highlights variations in chronic conditions and substance use across AIAN subpopulation groups.

Selected Findings

  • American Indian and Alaska Native (AIAN) adults in California experience substantial burdens of chronic conditions, including diabetes, heart disease, hypertension, and uncontrolled blood pressure, and of substance use including smoking, marijuana use, and binge drinking.
  •  These burdens are not shared equally across AIAN subpopulations, those with lower incomes or lower educational attainment reported higher rates of living with diabetes and uncontrolled blood pressure. 
  • Among AIAN adults living with hypertension, those identifying as lesbian, gay, bisexual, pansexual, or another nonheterosexual identity (LGBP+) were more than twice as likely as heterosexual adults to have uncontrolled blood pressure. 
  • Substance use also differed by income, with smoking more common among lower-incomes AIAN adults and binge drinking more common among higher-income adults.
  •  Marijuana use was markedly higher among LGBP+ and transgender and gender-expansive AIAN adults than their heterosexual and cisgender peers. 

Data Points

12%

AIAN adults in California have diabetes, similar to all California adults (11%).

1 in 5

AIAN adults in California with hypertension have uncontrolled high blood pressure (19%), compared with 12% of all California adults.

1 in 5

AIAN adults in California used marijuana (19%) or reported binge drinking (21%), both significantly higher than rates among California adults overall (15% and 18%, respectively).