Authors' objective was to characterize cardiovascular health in different migrant flows crossing through the United States (U.S.)-Mexico border region. Participants in a probability-based study of migrant flows completed cross-sectional surveys and measurements from February–December 2022 at transit points in Tijuana, Matamoros, and Ciudad Juárez, Mexico. Outcomes were American Heart Association cardiovascular health (CVH) metrics (diet, physical activity, nicotine exposure, body mass index, blood lipids, blood glucose, blood pressure) (all range 0–100). Covariate-adjusted linear regression was used to compare CVH outcomes by migration flow (Pre-migration, Return, Southbound, Deported). 

Findings: Compared to Pre-migration participants, Return and Southbound participants had significantly worse cardiovascular health scores for body mass index in adjusted models, while Deported participants had significantly lower scores for blood lipids . Two cardiovascular risk factors were identified that may serve as targets for intervention to improve cardiovascular health among migrants on the U.S.-Mexico border. Findings demonstrate that migration flows represent subpopulations whose health needs and barriers to health services differ. Transit points may be potential intervention venues to improve migrant health.