​The authors examined human papillomavirus vaccine awareness and acceptance between U.S.-born and U.S. foreign-born women by utilizing 2007 California Health Interview Survey data from 1,672 women (ages 18-27) and 2,994 mothers (ages 28-65). Foreign-born women and mothers had lower vaccine awareness. Foreign-born young adult Latinas had greater vaccine acceptance than U.S.-born Latinas. Other factors associated with young adult women's vaccine acceptability were being younger, unmarried, and sexually active in the past year; having poorer self-reported health; and having heard of the vaccine. Variables associated with mothers' vaccine acceptability were being white, insured, and unmarried; having had a Pap test in past 3 years; being less educated; and being impoverished.